Produktbeschreibung
Fisetin: A "rejuvenating treatment" for everyone who wants to defy aging.
High-purity fisetin as micronized powder
The biological aging process essentially takes place at the cellular level: Over the course of a lifetime, more and more cells cease to divide. They then die and are broken down by the organism. However, some do not die but remain in the system. These "old" cells, which have become useless to the organism, are scientifically referred to as senescent cells. It is considered proven that they play a causal role in aging and age-related diseases [1] because, among other things, they cause micro-inflammation.
Plant enzymes fight “zombie” cells
Some substances are known to be able to dissolve senescent cells (these are called senolytic substances). Plant flavonoids are particularly prominent among these. Recently, the polyphenol fisetin has become the focus of research: animal studies suggest that fisetin is an exceptionally potent senolytic agent. Of 10 flavonoids tested for senolytic activity, fisetin proved to be the most effective [2]! Oral administration of fisetin led to a delay in disease symptoms and an increased lifespan in the test animals.
Hundreds of times more concentrated than in nature
Fisetin is found in many fruits and vegetables, including strawberries, apples, peaches, grapes, kiwis, cucumbers, and onions. However, the amounts are very small. Strawberries, for example, contain only about 16 milligrams of fisetin per 100 g – and yet strawberries are already the richest edible plants in fisetin. Apples, grapes, onions, etc., have only a fraction of the fisetin content of strawberries. Our fisetin powder, on the other hand, is highly concentrated: It has a purity of 99%. The tin contains 50 g, which, theoretically, corresponds to the weight of over 300 kg of strawberries. Because the powder is micronized, it dissolves quickly and completely in water.
Application and dosage
Daily fisetin intake from normal fruit and vegetable consumption is less than 0.5 mg. This is far too little to produce a significant effect on cellular metabolism. Human studies with fisetin used dosages in the range of 100 mg per day [3]; however, many supplement manufacturers recommend even higher daily doses. At a daily dose of 500 mg, as is frequently recommended, one container of fisetin powder is sufficient for 100 days.
- laborjournal.de (2021): Senescence – Issue 3/2021 ( https://www.laborjournal.de/rubric/stichwort/stichwort/w_21_03.php )
- Matthew J Yousefzadeh et al. (2018): “Fisetin is a senotherapeutic that extends health and lifespan” ( https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.627533/full )
- Alireza Farsad-Naeimi et al. (2018): “Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients” ( https://pubmed.ncbi.nlm.nih.gov/29541713/ )